Ontology highlight
ABSTRACT:
SUBMITTER: Bharadwaj P
PROVIDER: S-EPMC7316712 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Bharadwaj Prashant P Solomon Tanya T Sahoo Bikash R BR Ignasiak Katarzyna K Gaskin Scott S Rowles Joanne J Verdile Giuseppe G Howard Mark J MJ Bond Charles S CS Ramamoorthy Ayyalusamy A Martins Ralph N RN Newsholme Philip P
Scientific reports 20200625 1
Human pancreatic islet amyloid polypeptide (hIAPP) and beta amyloid (Aβ) can accumulate in Type 2 diabetes (T2D) and Alzheimer's disease (AD) brains and evidence suggests that interaction between the two amyloidogenic proteins can lead to the formation of heterocomplex aggregates. However, the structure and consequences of the formation of these complexes remains to be determined. The main objective of this study was to characterise the different types and morphology of Aβ-hIAPP heterocomplexes ...[more]