Ontology highlight
ABSTRACT:
SUBMITTER: Chen C
PROVIDER: S-EPMC7316883 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Chen Cong C Liu Zuliang Z Liu Liguo L Wang Jianmin J Jin Qi Q
Frontiers in microbiology 20200619
H7N9 influenza virus was first isolated in 2013 and has caused five epidemic waves among humans to date. Treatment opinions are currently limited. Previously, we characterized a human neutralizing antibody, HNIgGA6, by isolating rearranged heavy- and light-chain genes from convalescent patients. The mAb disrupts viral attachment to the cellular receptor by directly interposing into the receptor binding site (RBS) and broadly neutralizing divergent H7N9 strains. To increase the protective efficac ...[more]