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Extending the Salinilactone Family.


ABSTRACT: Five new members of the salinilactone family, salinilactones D-H, are reported. These bicyclic lactones are produced by Salinispora bacteria and display extended or shortened alkyl side chains relative to the recently reported salinilactones A-C. They were identified by GC/MS, gas chromatographic retention index, and comparison with synthetic samples. We further investigated the occurrence of salinilactones across six newly proposed Salinispora species to gain insight into how compound production varies among taxa. The growth-inhibiting effect of this compound family on multiple biological systems including non-Salinispora actinomycetes was analyzed. Additionally, we found strong evidence for significant cytotoxicity of the title compounds.

SUBMITTER: Schlawis C 

PROVIDER: S-EPMC7317194 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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Extending the Salinilactone Family.

Schlawis Christian C   Harig Tim T   Ehlers Stephanie S   Guillen-Matus Dulce G DG   Creamer Kaitlin E KE   Jensen Paul R PR   Schulz Stefan S  

Chembiochem : a European journal of chemical biology 20200310 11


Five new members of the salinilactone family, salinilactones D-H, are reported. These bicyclic lactones are produced by Salinispora bacteria and display extended or shortened alkyl side chains relative to the recently reported salinilactones A-C. They were identified by GC/MS, gas chromatographic retention index, and comparison with synthetic samples. We further investigated the occurrence of salinilactones across six newly proposed Salinispora species to gain insight into how compound productio  ...[more]

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