Ontology highlight
ABSTRACT:
SUBMITTER: Kreuzahler M
PROVIDER: S-EPMC7318269 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Angewandte Chemie (International ed. in English) 20200406 24
Haloalkynylation reactions provide an efficient method for the simultaneous introduction of a halogen atom and an acetylenic unit. For the first time, we report a gold(I)-catalyzed haloalkynylation of aryl alkynes that delivers exclusively the cis addition product. This method enables the simple synthesis of conjugated and halogenated enynes in yields of up to 90 %. Notably, quantum chemical calculations reveal an exceptional interplay between the place of the attack at the chloroacetylene: No m ...[more]