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Insights into Cobalta(III/IV/II)-Electrocatalysis: Oxidation-Induced Reductive Elimination for Twofold C-H Activation.

ABSTRACT: The merger of cobalt-catalyzed C-H activation and electrosynthesis provides new avenues for resource-economical molecular syntheses, unfortunately their reaction mechanisms remain poorly understood. Herein, we report the identification and full characterization of electrochemically generated high-valent cobalt(III/IV) complexes as crucial intermediates in electrochemical cobalt-catalyzed C-H oxygenations. Detailed mechanistic studies provided support for an oxidatively-induced reductive elimination via highly-reactive cobalt(IV) intermediates. These key insights set the stage for unprecedented cobaltaelectro two-fold C-H/C-H activation.

SUBMITTER: Meyer TH

PROVIDER: S-EPMC7318662 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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Insights into Cobalta(III/IV/II)-Electrocatalysis: Oxidation-Induced Reductive Elimination for Twofold C-H Activation.

Meyer Tjark H TH Oliveira João C A JCA Ghorai Debasish D Ackermann Lutz L

Angewandte Chemie (International ed. in English) 20200505 27

The merger of cobalt-catalyzed C-H activation and electrosynthesis provides new avenues for resource-economical molecular syntheses, unfortunately their reaction mechanisms remain poorly understood. Herein, we report the identification and full characterization of electrochemically generated high-valent cobalt(III/IV) complexes as crucial intermediates in electrochemical cobalt-catalyzed C-H oxygenations. Detailed mechanistic studies provided support for an oxidatively-induced reductive eliminat ...[more]

PMID: 32154625

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