Ontology highlight
ABSTRACT:
SUBMITTER: Weigelt CM
PROVIDER: S-EPMC7318944 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Molecular cell 20200626 2
Circular RNAs (circRNAs) are abundant and accumulate with age in neurons of diverse species. However, only few circRNAs have been functionally characterized, and their role during aging has not been addressed. Here, we use transcriptome profiling during aging and find that accumulation of circRNAs is slowed down in long-lived insulin mutant flies. Next, we characterize the in vivo function of a circRNA generated by the sulfateless gene (circSfl), which is consistently upregulated, particularly i ...[more]