Ontology highlight
ABSTRACT:
SUBMITTER: Stefana MI
PROVIDER: S-EPMC5680271 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Stefana M Irina MI Driscoll Paul C PC Obata Fumiaki F Pengelly Ana Raquel AR Pengelly Ana Raquel AR Newell Clare L CL MacRae James I JI Gould Alex P AP
Nature communications 20171109 1
Early-life nourishment exerts long-term influences upon adult physiology and disease risk. These lasting effects of diet are well established but the underlying mechanisms are only partially understood. Here we show that restricting dietary yeast during Drosophila development can, depending upon the subsequent adult environment, more than double median lifespan. Developmental diet acts via a long-term influence upon the adult production of toxic molecules, which we term autotoxins, that are shed ...[more]