Ontology highlight
ABSTRACT:
SUBMITTER: Bose HS
PROVIDER: S-EPMC7334606 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Bose Himangshu S HS Marshall Brendan B Debnath Dilip K DK Perry Elizabeth W EW Whittal Randy M RM
iScience 20200620 7
The first steroidogenic enzyme, cytochrome P450-side-chain-cleavage (SCC), requires electron transport chain (ETC) complexes III and IV to initiate steroid metabolic processes for mammalian survival. ETC complex II, containing succinate dehydrogenase (quinone), acts with the TCA cycle and has no proton pumping capacity. We show that complex II is required for SCC activation through the proton pump, generating an intermediate state for addition of phosphate by succinate. Phosphate anions in the p ...[more]