Ontology highlight
ABSTRACT:
SUBMITTER: Bakker R
PROVIDER: S-EPMC7340504 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Bakker Rachael R Mani Madhav M Carthew Richard W RW
eLife 20200622
Morphogen signaling contributes to the patterned spatiotemporal expression of genes during development. One mode of regulation of signaling-responsive genes is at the level of transcription. Single-cell quantitative studies of transcription have revealed that transcription occurs intermittently, in bursts. Although the effects of many gene regulatory mechanisms on transcriptional bursting have been studied, it remains unclear how morphogen gradients affect this dynamic property of downstream gen ...[more]