Ontology highlight
ABSTRACT:
SUBMITTER: Gray S
PROVIDER: S-EPMC7341696 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Cell reports 20200701 1
During mammalian meiotic prophase I, programmed DNA double-strand breaks are repaired by non-crossover or crossover events, the latter predominantly occurring via the class I crossover pathway and requiring the cyclin N-terminal domain-containing 1(CNTD1) protein. Using an epitope-tagged Cntd1 allele, we detect a short isoform of CNTD1 in vivo that lacks a predicted N-terminal cyclin domain and does not bind cyclin-dependent kinases. Instead, we find that the short-form CNTD1 variant associates ...[more]