Ontology highlight
ABSTRACT:
SUBMITTER: McKay PF
PROVIDER: S-EPMC7347890 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Nature communications 20200709 1
The spread of the SARS-CoV-2 into a global pandemic within a few months of onset motivates the development of a rapidly scalable vaccine. Here, we present a self-amplifying RNA encoding the SARS-CoV-2 spike protein encapsulated within a lipid nanoparticle (LNP) as a vaccine. We observe remarkably high and dose-dependent SARS-CoV-2 specific antibody titers in mouse sera, as well as robust neutralization of both a pseudo-virus and wild-type virus. Upon further characterization we find that the neu ...[more]