In vivo diffusion-weighted MRS using semi-LASER in the human brain at 3 T: Methodological aspects and clinical feasibility.

ABSTRACT: Diffusion-weighted (DW-) MRS investigates non-invasively microstructural properties of tissue by probing metabolite diffusion in vivo. Despite the growing interest in DW-MRS for clinical applications, little has been published on the reproducibility of this technique. In this study, we explored the optimization of a single-voxel DW-semi-LASER sequence for clinical applications at 3 T, and evaluated the reproducibility of the method under different experimental conditions. DW-MRS measurements were carried out in 10 healthy participants and repeated across three sessions. Metabolite apparent diffusion coefficients (ADCs) were calculated from mono-exponential fits (ADC_exp ) up to b = 3300 s/mm² , and from the diffusional kurtosis approach (ADC_K ) up to b = 730

SUBMITTER: Genovese G 

PROVIDER: S-EPMC7354897 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature