Dataset Information

Insights into the genetic basis of HMGB1 in atrial fibrillation in a Chinese Han population.

ABSTRACT: Background:Atrial fibrillation (AF) is the most common cardiac arrhythmia. High mobility group box 1 (HMGB1) has been demonstrated to be involved in AF, but the genetic relationship between them is not clear yet. Here, we investigated the genetic association between functional variants in HMGB1 and AF in a Chinese Han population. Methods:Two common variants (the promoter one rs1045411T/C and the 3'UTR one rs1412125C/T) in HMGB1 were selected and genotyped in 576 AF patients and 869 control subjects. Traditional risk factors, such as age, gender, the history of smoking, hypertension and diabetes mellitus, were adjusted as covariates using a logistic regression analysis (SPSS, v.21.0). The haplotypic analysis was performed using SPSS (v.21.0, Inc., Chicago, IL, USA). Results:Under the allelic association analysis, neither rs1045411T/C nor rs1412125C/T was associated with AF with all P values >0.05; under the genotypic association analysis, the 3'UTR variant rs1045411T showed a marginally significant association with AF under the recessive model (Padj=0.056, OR =0.42; 95% CI: 0.17-1.02). When divided the studied population by gender, we still found no significant association results between the selected variants and AF with P values more than 0.05; however, when divided the population into subgroups by the age onset of AF, we found that the 3'UTR variant rs1045411T was significantly associated with AF in the late-onset subgroup (Padj=0.009, OR =11.1; 95% CI: 1.82-50.0). Conclusions:The 3'UTR variant rs1045411T/C of HMGB1 might influence the risk of late-onset AF in the Chinese Han population, which provides an important target factor for the prevention and treatment study of AF.

SUBMITTER: Li L

PROVIDER: S-EPMC7369288 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Insights into the genetic basis of <i>HMGB1</i> in atrial fibrillation in a Chinese Han population.

Li Li L Liu Yang Y Li Xinxin X Qiu Chunguang C

Cardiovascular diagnosis and therapy 20200601 3

<h4>Background</h4>Atrial fibrillation (AF) is the most common cardiac arrhythmia. High mobility group box 1 (HMGB1) has been demonstrated to be involved in AF, but the genetic relationship between them is not clear yet. Here, we investigated the genetic association between functional variants in <i>HMGB1</i> and AF in a Chinese Han population.<h4>Methods</h4>Two common variants (the promoter one rs1045411<sup>T/C</sup> and the 3'UTR one rs1412125<sup>C/T</sup>) in <i>HMGB1</i> were selected and ...[more]

PMID: 32695619

Similar Datasets

Project description:BackgroundPR interval variations have recently been associated with an increased risk of long-term atrial fibrillation (AF), heart block and all-cause mortality. Genome-wide association studies have linked the PR interval with several common variants in the TBX5 gene. Several variants in the TBX5 gene, including rs7312625 and rs883079, have been associated with AF. The purpose of this study was to determine the association of single-nucleotide polymorphisms (SNPs) in the TBX5 gene, rs7312625 and rs883079, with AF in Chinese Han patients.Methodology/principal findingsIn this case-control association study, large cohorts of AF patients (n = 1132) and controls (n = 1206) were recruited from different hospitals. The genotyping was performed using a Rotor-Gene TM 6000 high-resolution melt system. Rs7312625, rs3825214 and rs883079 were analyzed. We found that SNP 3825214 was significantly associated with AF (P-obs = 0.002, odds ratio [OR] = 0.82), and lone AF (P-obs = 6.77x10-5, odds ratio [OR] = 0.71). SNP rs7312625 was significantly associated with lone AF (P-obs = 0.015, odds ratio [OR] = 1.27), although its association with AF was not significant. No significant association of SNP rs883079 with AF or lone AF was observed. Thus, we analyzed the interaction among these three loci. We demonstrated significant interaction among rs3825214, rs7312625 and rs883079. Four-locus risk alleles showed the highest odds ratio in combined rs3825214 and rs7312625 (P-obs<0.0001, odds ratio [OR] = 2.21). Six-locus risk alleles showed the highest odds ratio in combined rs3825214, rs7312625 and rs 883079(P-obs<0.0001, odds ratio [OR] = 2.35). Significance was established with the trend test (P<0.0001).ConclusionsFor the first time, we report the strong association of SNP rs3825214 in the TBX5 gene with AF and lone AF in a Chinese Han population. Rs7312625 was significantly associated with lone AF, and snp-snp interaction increased the risk of atrial fibrillation. Our data might provide new insights into understanding AF pathogenesis and designing novel genetic therapies for AF patients.

Dataset Information

Insights into the genetic basis of HMGB1 in atrial fibrillation in a Chinese Han population.

Publications

Insights into the genetic basis of <i>HMGB1</i> in atrial fibrillation in a Chinese Han population.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets