Ontology highlight
ABSTRACT:
SUBMITTER: Alzubi J
PROVIDER: S-EPMC7372156 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Alzubi Jamal J Dettmer-Monaco Viviane V Kuehle Johannes J Thorausch Niko N Seidl Maximilian M Taromi Sanaz S Schamel Wolfgang W Zeiser Robert R Abken Hinrich H Cathomen Toni T Wolf Philipp P
Molecular therapy oncolytics 20200624
While chimeric antigen receptor (CAR) T cell immunotherapy targeting CD19 has shown remarkable success in patients with lymphoid malignancies, the potency of CAR T cells in solid tumors is low so far. To improve the efficacy of CAR T cells targeting prostate carcinoma, we designed a novel CAR that recognizes a new epitope in the prostate-specific membrane antigen (PSMA) and established novel paradigms to apply CAR T cells in a preclinical prostate cancer model. <i>In vitro</i> characterization o ...[more]