Dataset Information

VLDL-specific increases of fatty acids in autism spectrum disorder correlate with social interaction.

ABSTRACT: BACKGROUND:Abnormalities of lipid metabolism contributing to the autism spectrum disorder (ASD) pathogenesis have been suggested, but the mechanisms are not fully understood. We aimed to characterize the lipid metabolism in ASD and to explore a biomarker for clinical evaluation. METHODS:An age-matched case-control study was designed. Lipidomics was conducted using the plasma samples from 30 children with ASD compared to 30 typical developmental control (TD) children. Large-scale lipoprotein analyses were also conducted using the serum samples from 152 children with ASD compared to 122 TD children. Data comparing ASD to TD subjects were evaluated using univariate (Mann-Whitney test) and multivariate analyses (conditional logistic regression analysis) for main analyses using cofounders (diagnosis, sex, age, height, weight, and BMI), Spearman rank correlation coefficient, and discriminant analyses. FINDINGS:Forty-eight significant metabolites involved in lipid biosynthesis and metabolism, oxidative stress, and synaptic function were identified in the plasma of ASD children by lipidomics. Among these, increased fatty acids (FAs), such as omega-3 (n-3) and omega-6 (n-6), showed correlations with clinical social interaction score and ASD diagnosis. Specific reductions of very-low-density lipoprotein (VLDL) and apoprotein B (APOB) in serum of ASD children also were found by large-scale lipoprotein analysis. VLDL-specific reduction in ASD was correlated with APOB, indicating VLDL-specific dyslipidaemia associated with APOB in ASD children. INTERPRETATION:Our results demonstrated that the increases in FAs correlated positively with social interaction are due to VLDL-specific degradation, providing novel insights into the lipid metabolism underlying ASD pathophysiology. FUNDING:This study was supported mainly by MEXT, Japan.

SUBMITTER: Usui N

PROVIDER: S-EPMC7393524 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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VLDL-specific increases of fatty acids in autism spectrum disorder correlate with social interaction.

Usui Noriyoshi N Iwata Keiko K Miyachi Taishi T Takagai Shu S Wakusawa Keisuke K Nara Takahiro T Tsuchiya Kenji J KJ Matsumoto Kaori K Kurita Daisuke D Kameno Yosuke Y Wakuda Tomoyasu T Takebayashi Kiyokazu K Iwata Yasuhide Y Fujioka Toru T Hirai Takaharu T Toyoshima Manabu M Ohnishi Tetsuo T Toyota Tomoko T Maekawa Motoko M Yoshikawa Takeo T Maekawa Masato M Nakamura Kazuhiko K Tsujii Masatsugu M Sugiyama Toshiro T Mori Norio N Matsuzaki Hideo H

EBioMedicine 20200730

<h4>Background</h4>Abnormalities of lipid metabolism contributing to the autism spectrum disorder (ASD) pathogenesis have been suggested, but the mechanisms are not fully understood. We aimed to characterize the lipid metabolism in ASD and to explore a biomarker for clinical evaluation.<h4>Methods</h4>An age-matched case-control study was designed. Lipidomics was conducted using the plasma samples from 30 children with ASD compared to 30 typical developmental control (TD) children. Large-scale l ...[more]

PMID: 32739868

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Dataset Information

VLDL-specific increases of fatty acids in autism spectrum disorder correlate with social interaction.

Publications

VLDL-specific increases of fatty acids in autism spectrum disorder correlate with social interaction.

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