PET imaging of beta-secretase 1 in the human brain: radiation dosimetry, quantification, and test-retest examination of [¹⁸F]PF-06684511.

ABSTRACT:

Purpose

Beta-secretase 1 (BACE1) enzyme is implicated in the pathophysiology of Alzheimer's disease. [¹⁸F]PF-06684511 is a positron emission tomography (PET) radioligand for imaging BACE1. Despite favorable brain kinetic properties, the effective dose (ED) of [¹⁸F]PF-06684511 estimated in non-human primates was relatively high. This study was therefore designed to evaluate the whole-body distribution, dosimetry, quantification, and test-retest reliability of imaging brain BACE1 with [¹⁸F]PF-06684511 in healthy volunteers.

Methods

Five subjects were studied for the dosimetry study. Whole-body PET was performed for 366 min with 4 PET-CT sessions. Estimates of the absorbed radiation dose were calculated using the male adult model. Eight subjects

SUBMITTER: Arakawa R 

PROVIDER: S-EPMC7396399 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature