Quantification of [¹⁸F]florbetapir: A test-retest tracer kinetic modelling study.

ABSTRACT: Accumulation of amyloid beta can be visualized using [¹⁸F]florbetapir positron emission tomography. The aim of this study was to identify the optimal model for quantifying [¹⁸F]florbetapir uptake and to assess test-retest reliability of corresponding outcome measures. Eight Alzheimer's disease patients (age: 67 ± 6 years, Mini-Mental State Examination (MMSE): 23 ± 3) and eight controls (age: 63 ± 4 years, MMSE: 30 ± 0) were included. Ninety-minute dynamic positron emission tomography scans, together with arterial blood sampling, were acquired immediately following a bolus injection of 294 ± 32 MBq [¹⁸F]florbetapir. Several plasma input models and the simplified reference tissue model (SRTM) were evaluated. The Akaike information criterion was used to identi

SUBMITTER: Golla SS 

PROVIDER: S-EPMC6826855 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature