Engineered immunological niches to monitor disease activity and treatment efficacy in relapsing multiple sclerosis.
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ABSTRACT:
SUBMITTER: Morris AH
PROVIDER: S-EPMC7398910 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Publications
Engineered immunological niches to monitor disease activity and treatment efficacy in relapsing multiple sclerosis.
Morris Aaron H AH Hughes Kevin R KR Oakes Robert S RS Cai Michelle M MM Miller Stephen D SD Irani David N DN Shea Lonnie D LD
Nature communications 20200803 1
Relapses in multiple sclerosis can result in irreversible nervous system tissue injury. If these events could be detected early, targeted immunotherapy could potentially slow disease progression. We describe the use of engineered biomaterial-based immunological niches amenable to biopsy to provide insights into the phenotype of innate immune cells that control disease activity in a mouse model of multiple sclerosis. Differential gene expression in cells from these niches allow monitoring of dise ...[more]
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