Ontology highlight
ABSTRACT:
SUBMITTER: Danastas K
PROVIDER: S-EPMC7404291 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
International journal of molecular sciences 20200721 14
The interferon (IFN) system is one of the first lines of defense activated against invading viral pathogens. Upon secretion, IFNs activate a signaling cascade resulting in the production of several interferon stimulated genes (ISGs), which work to limit viral replication and establish an overall anti-viral state. Herpes simplex virus type 1 is a ubiquitous human pathogen that has evolved to downregulate the IFN response and establish lifelong latent infection in sensory neurons of the host. This ...[more]