Ontology highlight
ABSTRACT:
SUBMITTER: Yu L
PROVIDER: S-EPMC7406363 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Yu Lanlan L Zhang Wenbo W Luo Wendi W Dupont Robert L RL Xu Yang Y Wang Yibing Y Tu Bin B Xu Haiyan H Wang Xiaoguang X Fang Qiaojun Q Yang Yanlian Y Wang Chen C Wang Chenxuan C
Science advances 20200805 32
Selective oligomerization is a common phenomenon existing widely in the formation of intricate biological structures in nature. The precise design of drug molecules with an oligomerization state that specifically recognizes its receptor, however, remains substantially challenging. Here, we used scanning tunneling microscopy (STM) to identify the oligomerization states of an amyloid probe thioflavin T (ThT) on hIAPP<sub>8-37</sub> assembly to be exclusively even numbers. We demonstrate that both ...[more]