Ontology highlight
ABSTRACT:
SUBMITTER: Basiri B
PROVIDER: S-EPMC7415771 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Basiri Babak B Xie Fang F Wu Bin B Humphreys Sara C SC Lade Julie M JM Thayer Mai B MB Yamaguchi Pam P Florio Monica M Rock Brooke M BM
Molecular therapy. Nucleic acids 20200710
There has been a renewed interest in therapeutic small interfering RNAs (siRNAs) over the past few years. This is particularly the result of successful and efficient delivery of N-acetylgalactosamine (GalNAc)-conjugated siRNAs to the liver. In general, the lead selection process for siRNA drugs is faster and more straightforward than traditional small molecules. Nevertheless, many siRNAs of different sequences and chemical modification patterns must still be evaluated before arriving at a final ...[more]