Ontology highlight
ABSTRACT:
SUBMITTER: Finn EH
PROVIDER: S-EPMC7421438 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Finn Elizabeth H EH Misteli Tom T
Science (New York, N.Y.) 20190901 6457
The complex three-dimensional organization of genomes in the cell nucleus arises from a wide range of architectural features including DNA loops, chromatin domains, and higher-order compartments. Although these features are universally present in most cell types and tissues, recent single-cell biochemistry and imaging approaches have demonstrated stochasticity in transcription and high variability of chromatin architecture in individual cells. We review the occurrence, mechanistic basis, and fun ...[more]