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Spatial genome organization and cognition.

ABSTRACT: Nonrandom chromosomal conformations, including promoter-enhancer loopings that bypass kilobases or megabases of linear genome, provide a crucial layer of transcriptional regulation and move vast amounts of non-coding sequence into the physical proximity of genes that are important for neurodevelopment, cognition and behaviour. Activity-regulated changes in the neuronal '3D genome' could govern transcriptional mechanisms associated with learning and plasticity, and loop-bound intergenic and intronic non-coding sequences have been implicated in psychiatric and adult-onset neurodegenerative disease. Recent studies have begun to clarify the roles of spatial genome organization in normal and abnormal cognition.

SUBMITTER: Rajarajan P

PROVIDER: S-EPMC5503467 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature

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Spatial genome organization and cognition.

Rajarajan Prashanth P Gil Sergio Espeso SE Brennand Kristen J KJ Akbarian Schahram S

Nature reviews. Neuroscience 20161006 11

Nonrandom chromosomal conformations, including promoter-enhancer loopings that bypass kilobases or megabases of linear genome, provide a crucial layer of transcriptional regulation and move vast amounts of non-coding sequence into the physical proximity of genes that are important for neurodevelopment, cognition and behaviour. Activity-regulated changes in the neuronal '3D genome' could govern transcriptional mechanisms associated with learning and plasticity, and loop-bound intergenic and intro ...[more]

PMID: 27708356

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