Ontology highlight
ABSTRACT:
SUBMITTER: Ghraichy M
PROVIDER: S-EPMC7424015 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Ghraichy Marie M Galson Jacob D JD Kovaltsuk Aleksandr A von Niederhäusern Valentin V Pachlopnik Schmid Jana J Recher Mike M Jauch Annaïse J AJ Miho Enkelejda E Kelly Dominic F DF Deane Charlotte M CM Trück Johannes J
Frontiers in immunology 20200806
B cells play a central role in adaptive immune processes, mainly through the production of antibodies. The maturation of the B cell system with age is poorly studied. We extensively investigated age-related alterations of naïve and antigen-experienced immunoglobulin heavy chain (IgH) repertoires. The most significant changes were observed in the first 10 years of life, and were characterized by altered immunoglobulin gene usage and an increased frequency of mutated antibodies structurally diverg ...[more]