Ontology highlight
ABSTRACT:
SUBMITTER: Hayden L
PROVIDER: S-EPMC7427287 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Hayden Lorna L Semenoff Tiia T Schultz Verena V Merz Simon F SF Chapple Katie J KJ Rodriguez Moses M Warrington Arthur E AE Shi Xiaohong X McKimmie Clive S CS Edgar Julia M JM Thümmler Katja K Linington Chris C Pingen Marieke M
Acta neuropathologica communications 20200813 1
Progressive multi-focal leukoencephalopathy (PML) is a potentially fatal encephalitis caused by JC polyomavirus (JCV). PML principally affects people with a compromised immune system, such as patients with multiple sclerosis (MS) receiving treatment with natalizumab. However, intrathecal synthesis of lipid-reactive IgM in MS patients is associated with a markedly lower incidence of natalizumab-associated PML compared to those without this antibody repertoire. Here we demonstrate that a subset of ...[more]