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Rh(III)-Catalyzed Cyclopropanation of Unactivated Olefins Initiated by C-H Activation.

ABSTRACT: We have developed a Rh(III)-catalyzed cyclopropanation of unactivated olefins initiated by an alkenyl C-H activation. A variety of 1,1-disubstituted olefins undergo efficient cyclopropanation with a slight excess of alkene stoichiometry. A series of mechanistic interrogations implicate a metal-carbene as an intermediate.

SUBMITTER: Phipps EJT 

PROVIDER: S-EPMC7428168 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature

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Rh(III)-Catalyzed Cyclopropanation of Unactivated Olefins Initiated by C-H Activation.

Phipps Erik J T EJT   Piou Tiffany T   Rovis Tomislav T  

Synlett : accounts and rapid communications in synthetic organic chemistry 20190722 15

We have developed a Rh(III)-catalyzed cyclopropanation of unactivated olefins initiated by an alkenyl C-H activation. A variety of 1,1-disubstituted olefins undergo efficient cyclopropanation with a slight excess of alkene stoichiometry. A series of mechanistic interrogations implicate a metal-carbene as an intermediate. ...[more]

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