Ontology highlight
ABSTRACT:
SUBMITTER: Hao YN
PROVIDER: S-EPMC7428381 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Journal of materials chemistry. B 20190829 43
Here we report a novel mechanism for triggering drug release in the polydopamine (PDA)-coated magnetic CuCo<sub>2</sub>S<sub>4</sub> core-shell nanostructure by glutathione (GSH) triggered degradation of PDA for release. In the design, we used PDA coated CuCo<sub>2</sub>S<sub>4</sub> as the nanocarrier with polyethylene glycol and folic acid targeting molecules to ensure the safe delivery of doxorubicin (DOX) to cancer cells. In addition, the controlled release could be enforced by taking advant ...[more]