Ontology highlight
ABSTRACT:
SUBMITTER: Erb U
PROVIDER: S-EPMC7432056 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Erb Ulrike U Hikel Julia J Meyer Svenja S Ishikawa Hiroshi H Worst Thomas S TS Nitschke Katja K Nuhn Philipp P Porubsky Stefan S Weiss Christel C Schroten Horst H Adam Rüdiger R Karremann Michael M
International journal of molecular sciences 20200731 15
Central nervous System (CNS) disease in pediatric acute lymphoblastic leukemia (ALL) is a major concern, but still, cellular mechanisms of CNS infiltration are elusive. The choroid plexus (CP) is a potential entry site, and, to some extent, invasion resembles CNS homing of lymphocytes during healthy state. Given exosomes may precondition target tissue, the present work aims to investigate if leukemia-derived exosomes contribute to a permissive phenotype of the blood-cerebrospinal fluid barrier ( ...[more]