Ontology highlight
ABSTRACT:
SUBMITTER: Yoon YM
PROVIDER: S-EPMC7432329 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Yoon Yeo Min YM Go Gyeongyun G Yun Chul Won CW Lim Ji Ho JH Lee Jun Hee JH Lee Sang Hun SH
International journal of molecular sciences 20200727 15
Renal fibrosis, a major risk factor for kidney failure, can lead to chronic kidney disease (CKD) and is caused by cytoskeleton reorganization and mitochondrial dysfunction. In this study, we investigated the potential of melatonin treatment to reduce renal fibrosis by recovering the cytoskeleton reorganization and mitochondrial dysfunction. We found that miR-4516 expression was downregulated in the renal cortex of CKD mice and <i>P</i>-cresol-treated TH1 cells. Decreased miR-4516 expression stim ...[more]