Ontology highlight
ABSTRACT:
SUBMITTER: Wei Z
PROVIDER: S-EPMC7435646 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Wei Zhuocai Z Tan Jie J Cui Xinhua X Zhou Min M Huang Yunhou Y Zang Ning N Chen Zhaoni Z Wei Wanxing W
Molecules (Basel, Switzerland) 20200724 15
Oxime derivatives of dehydrocholic acid and its esters were designed for anti-hepatitis B virus (HBV) drugs according to principles of assembling active chemical fragments. Twelve compounds were synthesized from dehydrocholic acid by esterification and oxime formation, and their anti-hepatitis B virus (HBV) activities were evaluated with HepG 2.2.15 cells. Results showed that 5 compounds exhibited more effective inhibition of HBeAg than positive control, among them <b>2b-3</b> and <b>2b-1</b> sh ...[more]