Ontology highlight
ABSTRACT:
SUBMITTER: Huang JH
PROVIDER: S-EPMC7443003 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Huang Jian-Hua JH He Dan D Chen Lin L Du Qing Q Yu Rong R Cai Ping P Zhang Shui-Han SH
International journal of analytical chemistry 20200813
<h4>Materials and methods</h4>MKR mice were used for the development of diabetes with high-fat diet feeding. These mice were further injected with streptozocin (STZ) to aggravate kidney failure. Fasting blood glucose (FBG) and urinary albumin-to-creatinine ratio (ACR values) were determined to validate the successful establishment of diabetic models with desired kidney dysfunction. Metabolomics approach coupled with gas chromatography-mass spectrometry (GC-MS) and random forest (RF) algorithm wa ...[more]