The Association between Trimethylamine N-Oxide and Its Predecessors Choline, L-Carnitine, and Betaine with Coronary Artery Disease and Artery Stenosis.

ABSTRACT:

Background

Trimethylamine N-oxide (TMAO) and its predecessor products, choline, L-carnitine, and betaine, were reported to be associated with cardiovascular events risk. However, the association of TMAO and its predecessors with extent of artery stenosis in coronary artery disease (CAD) and in different gender is still unknown. Our aim is to investigate the association of plasma TMAO and its predecessors in CAD and extent of artery lesion in different gender.

Methods

94 CAD patients and 75 healthy controls (CON) were enrolled. Fasting plasma TMAO, choline, L-carnitine, and betaine were detected using liquid chromatography-tandem mass spectrometry.

Results

Elevated plasma TMAO but not choline, L-carnitine, or betaine was observed in CAD (1.46(0.8-2.32) μM) and s

SUBMITTER: Guo F 

PROVIDER: S-EPMC7443013 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature