Ontology highlight
ABSTRACT:
SUBMITTER: Wang S
PROVIDER: S-EPMC7447770 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Wang Shuxiong S Drummond Michael L ML Guerrero-Juarez Christian F CF Tarapore Eric E MacLean Adam L AL Stabell Adam R AR Wu Stephanie C SC Gutierrez Guadalupe G That Bao T BT Benavente Claudia A CA Nie Qing Q Atwood Scott X SX
Nature communications 20200825 1
How stem cells give rise to epidermis is unclear despite the crucial role the epidermis plays in barrier and appendage formation. Here we use single cell-RNA sequencing to interrogate basal stem cell heterogeneity of human interfollicular epidermis and find four spatially distinct stem cell populations at the top and bottom of rete ridges and transitional positions between the basal and suprabasal epidermal layers. Cell-cell communication modeling suggests that basal cell populations serve as cr ...[more]