Ontology highlight
ABSTRACT:
SUBMITTER: Narva S
PROVIDER: S-EPMC7450630 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Narva Suresh S Xiong Xuqiong X Ma Xudong X Tanaka Yoshimasa Y Wu Yanling Y Zhang Wen W
ACS omega 20200814 33
In this study, we designed and synthesized a series of 3-(4-((5-((2-methylbiphenyl-3-yl) methoxy)-2-(piperazin-1-ylmethyl)phenoxy)methyl)-1<i>H</i>-1,2,3-triazol-1-yl)benzonitrile derivatives and examined the effect of the compounds on the interaction between PD-1 and PD-L1. Among the newly synthesized compounds, compound <b>7</b> exhibited the most potent inhibitory activity for PD-1/PD-L1 binding, with an IC<sub>50</sub> value being 8.52 μM, through homogeneous time-resolved fluorescence (HTRF ...[more]