Ontology highlight
ABSTRACT:
SUBMITTER: Cinque L
PROVIDER: S-EPMC7459426 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Cinque Laura L De Leonibus Chiara C Iavazzo Maria M Krahmer Natalie N Intartaglia Daniela D Salierno Francesco Giuseppe FG De Cegli Rossella R Di Malta Chiara C Svelto Maria M Lanzara Carmela C Maddaluno Marianna M Wanderlingh Luca Giorgio LG Huebner Antje K AK Cesana Marcella M Bonn Florian F Polishchuk Elena E Hübner Christian A CA Conte Ivan I Dikic Ivan I Mann Matthias M Ballabio Andrea A Sacco Francesca F Grumati Paolo P Settembre Carmine C
The EMBO journal 20200727 17
Lysosomal degradation of the endoplasmic reticulum (ER) via autophagy (ER-phagy) is emerging as a critical regulator of cell homeostasis and function. The recent identification of ER-phagy receptors has shed light on the molecular mechanisms underlining this process. However, the signaling pathways regulating ER-phagy in response to cellular needs are still largely unknown. We found that the nutrient responsive transcription factors TFEB and TFE3-master regulators of lysosomal biogenesis and aut ...[more]