Ontology highlight
ABSTRACT:
SUBMITTER: Papadimitriou K
PROVIDER: S-EPMC7463609 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Cancers 20200722 8
Multiple myeloma (MM) remains incurable despite the abundance of novel drugs. As it has been previously shown, preclinical 2D models fail to predict disease progression due to their inability to simulate the microenvironment of the bone marrow. In this review, we focus on 3D models and present all currently available ex vivo MM models that fulfil certain criteria, such as development of complex 3D environments using patients' cells and ability to test different drugs in order to assess personali ...[more]