Ontology highlight
ABSTRACT:
SUBMITTER: Kontogiannidou E
PROVIDER: S-EPMC7463809 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Kontogiannidou Eleni E Meikopoulos Thomas T Gika Helen H Panteris Emmanuel E Vizirianakis Ioannis S IS Müllertz Anette A Fatouros Dimitrios G DG
Pharmaceutics 20200725 8
Amphotericin B (AmpB), one of the most commonly used agents in the treatment of severe fungal infections and life-threatening parasitic diseases such as visceral Leishmaniasis, has a negligible oral bioavailability, primarily due to a low solubility and permeability. To develop an oral formulation, medium chain triglycerides and nonionic surfactants in a self-nano-emulsifying drug delivery system (SNEDDS) containing AmpB were combined with room temperature ionic liquids (RTILs) of imidazolium. T ...[more]