Unknown

Dataset Information

0

In Vitro Evaluation of Self-Nano-Emulsifying Drug Delivery Systems (SNEDDS) Containing Room Temperature Ionic Liquids (RTILs) for the Oral Delivery of Amphotericin B.


ABSTRACT: Amphotericin B (AmpB), one of the most commonly used agents in the treatment of severe fungal infections and life-threatening parasitic diseases such as visceral Leishmaniasis, has a negligible oral bioavailability, primarily due to a low solubility and permeability. To develop an oral formulation, medium chain triglycerides and nonionic surfactants in a self-nano-emulsifying drug delivery system (SNEDDS) containing AmpB were combined with room temperature ionic liquids (RTILs) of imidazolium. The presence of ionic liquids significantly enhanced the solubility of AmpB, exhibited a low toxicity and increased the transport of AmpB across Caco-2 cell monolayers. The combination of RTILs with a lipid formulation might be a promising strategy to improve the oral bioavailability of AmpB.

SUBMITTER: Kontogiannidou E 

PROVIDER: S-EPMC7463809 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature

altmetric image

Publications

In Vitro Evaluation of Self-Nano-Emulsifying Drug Delivery Systems (SNEDDS) Containing Room Temperature Ionic Liquids (RTILs) for the Oral Delivery of Amphotericin B.

Kontogiannidou Eleni E   Meikopoulos Thomas T   Gika Helen H   Panteris Emmanuel E   Vizirianakis Ioannis S IS   Müllertz Anette A   Fatouros Dimitrios G DG  

Pharmaceutics 20200725 8


Amphotericin B (AmpB), one of the most commonly used agents in the treatment of severe fungal infections and life-threatening parasitic diseases such as visceral Leishmaniasis, has a negligible oral bioavailability, primarily due to a low solubility and permeability. To develop an oral formulation, medium chain triglycerides and nonionic surfactants in a self-nano-emulsifying drug delivery system (SNEDDS) containing AmpB were combined with room temperature ionic liquids (RTILs) of imidazolium. T  ...[more]

Similar Datasets

| S-EPMC8146397 | biostudies-literature
| S-EPMC8147608 | biostudies-literature
| S-EPMC4777308 | biostudies-literature
| S-EPMC6507529 | biostudies-literature
| S-EPMC6627579 | biostudies-literature
| S-EPMC3951289 | biostudies-literature
| S-EPMC6099736 | biostudies-literature
| S-EPMC7411987 | biostudies-literature
| S-EPMC7070553 | biostudies-literature
| S-EPMC7874248 | biostudies-literature