Ontology highlight
ABSTRACT:
SUBMITTER: Mikhtaniuk SE
PROVIDER: S-EPMC7464546 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Mikhtaniuk Sofia E SE Bezrodnyi Valeriy V VV Shavykin Oleg V OV Neelov Igor M IM Sheveleva Nadezhda N NN Penkova Anastasia V AV Markelov Denis A DA
Polymers 20200725 8
In this paper, we perform computer simulation of two lysine-based dendrimers with Lys-2Lys and Lys-2Gly repeating units. These dendrimers were recently studied experimentally by NMR (Sci. Reports, 2018, 8, 8916) and tested as carriers for gene delivery (Bioorg. Chem., 2020, 95, 103504). Simulation was performed by molecular dynamics method in a wide range of temperatures. We have shown that the Lys-2Lys dendrimer has a larger size but smaller fluctuations as well as lower internal density in com ...[more]