Ontology highlight
ABSTRACT:
SUBMITTER: Zhao ZJ
PROVIDER: S-EPMC7467278 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Zhao Zhan-Juan ZJ Xu Zeng-Ping ZP Ma Ying-Ying YY Ma Jin-Duo JD Hong Ge G
PloS one 20200902 9
This study examined the antibacterial effect of protoporphyrin IX-ethylenediamine derivative (PPIX-ED)-mediated photodynamic antimicrobial chemotherapy (PPIX-ED-PACT) against Pseudomonas aeruginosa in vitro and in vivo. PPIX-ED potently inhibited the growth of Pseudomonas aeruginosa by inducing reactive oxygen species production via photoactivation. Atomic force microscopy revealed that PPIX-ED-PACT induced the leakage of bacterial content by degrading the bacterial membrane and wall. As reveale ...[more]