TDG is a novel tumor suppressor of liver malignancies.
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ABSTRACT:
SUBMITTER: Hassan HM
PROVIDER: S-EPMC7469547 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
TDG is a novel tumor suppressor of liver malignancies.
Hassan Haider M HM Isovic Majdina M Underhill Michael Tully MT Torchia Joseph J
Molecular & cellular oncology 20200617 4
In a recent publication, we demonstrated that conditional deletion of the gene encoding thymine DNA glycosylase (TDG) leads to a late onset of hepatocellular carcinoma (HCC). TDG loss causes disruption in active DNA demethylation in the liver and dysregulation of the farnesoid X receptor and small heterodimer partner (FXR-SHP) regulatory cascade. This leads to a loss of bile acid and glucose homeostasis, which predisposes mice to HCC. ...[more]
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