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Pharmacologic Manipulation of Wnt Signaling and Cancer Stem Cells.

ABSTRACT: Wnt (Wingless-related integration site)-signaling orchestrates self-renewal programs in normal somatic stem cells as well as in cancer stem cells. Aberrant Wnt signaling is associated with a wide variety of malignancies and diseases. Although our understanding has increased tremendously over the past decade, therapeutic targeting of the dysregulated Wnt pathway remains a challenge. Here we review recent preclinical and clinical therapeutic approaches to target the Wnt pathway.

SUBMITTER: Duchartre Y

PROVIDER: S-EPMC7473415 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Pharmacologic Manipulation of Wnt Signaling and Cancer Stem Cells.

Duchartre Yann Y Kim Yong-Mi YM Kahn Michael M

Methods in molecular biology (Clifton, N.J.) 20170101

Wnt (Wingless-related integration site)-signaling orchestrates self-renewal programs in normal somatic stem cells as well as in cancer stem cells. Aberrant Wnt signaling is associated with a wide variety of malignancies and diseases. Although our understanding has increased tremendously over the past decade, therapeutic targeting of the dysregulated Wnt pathway remains a challenge. Here we review recent preclinical and clinical therapeutic approaches to target the Wnt pathway. ...[more]

PMID: 28849572

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