Ontology highlight
ABSTRACT:
SUBMITTER: Monje-Galvan V
PROVIDER: S-EPMC7476761 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Monje-Galvan Viviana V Voth Gregory A GA
eLife 20200818
Specific protein-lipid interactions are critical for viral assembly. We present a molecular dynamics simulation study on the binding mechanism of the membrane targeting domain of HIV-1 Gag protein. The matrix (MA) domain drives Gag onto the plasma membrane through electrostatic interactions at its highly-basic-region (HBR), located near the myristoylated (Myr) N-terminus of the protein. Our study suggests Myr insertion is involved in the sorting of membrane lipids around the protein-binding site ...[more]