First Report of Sorafenib in Patients With Acute Myeloid Leukemia Harboring Non-Canonical FLT3 Mutations.
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ABSTRACT:
SUBMITTER: Daver N
PROVIDER: S-EPMC7479234 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
First Report of Sorafenib in Patients With Acute Myeloid Leukemia Harboring Non-Canonical <i>FLT3</i> Mutations.
Daver Naval N Price Allyson A Benton Christopher B CB Patel Keyur K Zhang Weiguo W Konopleva Marina M Pemmaraju Naveen N Takahashi Koichi K Andreeff Michael M Borthakur Gautam G
Frontiers in oncology 20200826
The prognostics implications of patients with acute myeloid leukemia harboring non-canonical <i>FLT3</i> is unknown. The use of tyrosine kinase inhibitors in this patient population has not been previously reported. We report successful targeted therapy against non-ITD, non-D835 driver <i>FLT3</i> alterations in two patient case studies with acute myeloid leukemia. ...[more]
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