Ontology highlight
ABSTRACT:
SUBMITTER: Paul DM
PROVIDER: S-EPMC7480112 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Paul Danielle M DM Mantell Judith J Borucu Ufuk U Coombs Jennifer J Surridge Katherine J KJ Squire John M JM Verkade Paul P Dodding Mark P MP
The Journal of cell biology 20200901 9
Microtubules and filamentous (F-) actin engage in complex interactions to drive many cellular processes from subcellular organization to cell division and migration. This is thought to be largely controlled by proteins that interface between the two structurally distinct cytoskeletal components. Here, we use cryo-electron tomography to demonstrate that the microtubule lumen can be occupied by extended segments of F-actin in small molecule-induced, microtubule-based, cellular projections. We unco ...[more]