Ontology highlight
ABSTRACT:
SUBMITTER: Erdmann PS
PROVIDER: S-EPMC8433212 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Erdmann Philipp S PS Hou Zhen Z Klumpe Sven S Khavnekar Sagar S Beck Florian F Wilfling Florian F Plitzko Jürgen M JM Baumeister Wolfgang W
Nature communications 20210910 1
Ribosomes comprise a large (LSU) and a small subunit (SSU) which are synthesized independently in the nucleolus before being exported into the cytoplasm, where they assemble into functional ribosomes. Individual maturation steps have been analyzed in detail using biochemical methods, light microscopy and conventional electron microscopy (EM). In recent years, single particle analysis (SPA) has yielded molecular resolution structures of several pre-ribosomal intermediates. It falls short, however ...[more]