Ontology highlight
ABSTRACT:
SUBMITTER: Kiwada T
PROVIDER: S-EPMC7481701 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Kiwada Tatsuto T Katakasu Hiromu H Okumura Serina S Odani Akira A
Royal Society open science 20200819 8
Proteasome inhibitors are useful for biochemical research and clinical treatment. In our previous study, we reported that the 4N-coordinated platinum complexes with anthracenyl ring and heterocycle exhibited proteasome-inhibitory activity. In the present study, the structure-activity relationships and characterization of these complexes were determined for the elucidation of the role of aromatic ligands. Lineweaver-Burk analysis revealed that the chemical structure of heterocycles affects the bi ...[more]