Ontology highlight
ABSTRACT:
SUBMITTER: Liepe J
PROVIDER: S-EPMC2891702 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Liepe Juliane J Mishto Michele M Textoris-Taube Kathrin K Janek Katharina K Keller Christin C Henklein Petra P Kloetzel Peter Michael PM Zaikin Alexey A
PLoS computational biology 20100624 6
The identification of proteasome-generated spliced peptides (PSP) revealed a new unpredicted activity of the major cellular protease. However, so far characterization of PSP was entirely dependent on the availability of patient-derived cytotoxic CD8+ T lymphocytes (CTL) thus preventing a systematic investigation of proteasome-catalyzed peptide splicing (PCPS). For an unrestricted PSP identification we here developed SpliceMet, combining the computer-based algorithm ProteaJ with in vitro proteaso ...[more]