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Radiation-induced lung toxicity - cellular and molecular mechanisms of pathogenesis, management, and literature review.


ABSTRACT: Lung, breast, and esophageal cancer represent three common malignancies with high incidence and mortality worldwide. The management of these tumors critically relies on radiotherapy as a major part of multi-modality care, and treatment-related toxicities, such as radiation-induced pneumonitis and/or lung fibrosis, are important dose limiting factors with direct impact on patient outcomes and quality of life. In this review, we summarize the current understanding of radiation-induced pneumonitis and pulmonary fibrosis, present predictive factors as well as recent diagnostic and therapeutic advances. Novel candidates for molecularly targeted approaches to prevent and/or treat radiation-induced pneumonitis and pulmonary fibrosis are discussed.

SUBMITTER: Kasmann L 

PROVIDER: S-EPMC7488099 | biostudies-literature |

REPOSITORIES: biostudies-literature

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