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Molecular and Cellular Mechanisms for PRRSV Pathogenesis and Host Response to Infection.

ABSTRACT: Porcine reproductive and respiratory syndrome virus (PRRSV) has caused tremendous amounts of economic losses to the swine industry for more than three decades, but its control is still unsatisfactory. A significant amount of information is available for host cell-virus interactions during infection, and it is evident that PRRSV has evolved to equip various strategies to disrupt the host antiviral system and provide favorable conditions for survival. The current study reviews viral strategies for modulations of cellular processes including innate immunity, apoptosis, microRNAs, inflammatory cytokines, and other cellular pathways.

SUBMITTER: An TQ

PROVIDER: S-EPMC7165118 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

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Molecular and Cellular Mechanisms for PRRSV Pathogenesis and Host Response to Infection.

An Tong-Qing TQ Li Jiang-Nan JN Su Chia-Ming CM Yoo Dongwan D

Virus research 20200418

Porcine reproductive and respiratory syndrome virus (PRRSV) has caused tremendous amounts of economic losses to the swine industry for more than three decades, but its control is still unsatisfactory. A significant amount of information is available for host cell-virus interactions during infection, and it is evident that PRRSV has evolved to equip various strategies to disrupt the host antiviral system and provide favorable conditions for survival. The current study reviews viral strategies for ...[more]

PMID: 32311386

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