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Ribosomal Incorporation of Aromatic Oligoamides as Peptide Sidechain Appendages.


ABSTRACT: Derivatives of 4-aminomethyl-l-phenylalanine with aromatic oligoamide foldamers as sidechain appendages were successfully charged on tRNA by means of flexizymes. Their subsequent incorporation both at the C-terminus of, and within, peptide sequences by the ribosome, was demonstrated. These results expand the registry of chemical structures tolerated by the ribosome to sidechains significantly larger and more structurally defined than previously demonstrated.

SUBMITTER: Tsiamantas C 

PROVIDER: S-EPMC7496375 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature

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Ribosomal Incorporation of Aromatic Oligoamides as Peptide Sidechain Appendages.

Tsiamantas Christos C   Kwon Sunbum S   Rogers Joseph M JM   Douat Céline C   Huc Ivan I   Suga Hiroaki H  

Angewandte Chemie (International ed. in English) 20200204 12


Derivatives of 4-aminomethyl-l-phenylalanine with aromatic oligoamide foldamers as sidechain appendages were successfully charged on tRNA by means of flexizymes. Their subsequent incorporation both at the C-terminus of, and within, peptide sequences by the ribosome, was demonstrated. These results expand the registry of chemical structures tolerated by the ribosome to sidechains significantly larger and more structurally defined than previously demonstrated. ...[more]

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